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ABSTRACT: Objective
Accurate real-time continuous glucose measurements may improve glucose control in the critical care unit. We evaluated the accuracy of the FreeStyle(®) Navigator(®) (Abbott Diabetes Care, Alameda, CA) subcutaneous continuous glucose monitoring (CGM) device in critically ill adults using two methods of calibration.Subjects and methods
In a randomized trial, paired CGM and reference glucose (hourly arterial blood glucose [ABG]) were collected over a 48-h period from 24 adults with critical illness (mean±SD age, 60±14 years; mean±SD body mass index, 29.6±9.3?kg/m(2); mean±SD Acute Physiology and Chronic Health Evaluation score, 12±4 [range, 6-19]) and hyperglycemia. In 12 subjects, the CGM device was calibrated at variable intervals of 1-6?h using ABG. In the other 12 subjects, the sensor was calibrated according to the manufacturer's instructions (1, 2, 10, and 24?h) using arterial blood and the built-in point-of-care glucometer.Results
In total, 1,060 CGM-ABG pairs were analyzed over the glucose range from 4.3 to 18.8?mmol/L. Using enhanced calibration median (interquartile range) every 169 (122-213) min, the absolute relative deviation was lower (7.0% [3.5, 13.0] vs. 12.8% [6.3, 21.8], P<0.001), and the percentage of points in the Clarke error grid Zone A was higher (87.8% vs. 70.2%).Conclusions
Accuracy of the Navigator CGM device during critical illness was comparable to that observed in non-critical care settings. Further significant improvements in accuracy may be obtained by frequent calibrations with ABG measurements.
SUBMITTER: Leelarathna L
PROVIDER: S-EPMC3894676 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Leelarathna Lalantha L English Shane W SW Thabit Hood H Caldwell Karen K Allen Janet M JM Kumareswaran Kavita K Wilinska Malgorzata E ME Nodale Marianna M Haidar Ahmad A Evans Mark L ML Burnstein Rowan R Hovorka Roman R
Diabetes technology & therapeutics 20131104 2
<h4>Objective</h4>Accurate real-time continuous glucose measurements may improve glucose control in the critical care unit. We evaluated the accuracy of the FreeStyle(®) Navigator(®) (Abbott Diabetes Care, Alameda, CA) subcutaneous continuous glucose monitoring (CGM) device in critically ill adults using two methods of calibration.<h4>Subjects and methods</h4>In a randomized trial, paired CGM and reference glucose (hourly arterial blood glucose [ABG]) were collected over a 48-h period from 24 ad ...[more]