Ontology highlight
ABSTRACT:
SUBMITTER: Amatrudo JM
PROVIDER: S-EPMC3894722 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Amatrudo Joseph M JM Olson Jeremy P JP Lur G G Chiu Chiayu Q CQ Higley Michael J MJ Ellis-Davies Graham C R GC
ACS chemical neuroscience 20131204 1
We have synthesized photolabile 7-diethylamino coumarin (DEAC) derivatives of γ-aminobutyric acid (GABA). These caged neurotransmitters efficiently release GABA using linear or nonlinear excitation. We used a new DEAC-based caging chromophore that has a vinyl acrylate substituent at the 3-position that shifts the absorption maximum of DEAC to about 450 nm and thus is named "DEAC450". DEAC450-caged GABA is photolyzed with a quantum yield of 0.39 and is highly soluble and stable in physiological b ...[more]