Ontology highlight
ABSTRACT:
SUBMITTER: Malvindi MA
PROVIDER: S-EPMC3897540 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Malvindi Maria Ada MA De Matteis Valeria V Galeone Antonio A Brunetti Virgilio V Anyfantis George C GC Athanassiou Athanassia A Cingolani Roberto R Pompa Pier Paolo PP
PloS one 20140121 1
We have studied in vitro toxicity of iron oxide nanoparticles (NPs) coated with a thin silica shell (Fe3O4/SiO2 NPs) on A549 and HeLa cells. We compared bare and surface passivated Fe3O4/SiO2 NPs to evaluate the effects of the coating on the particle stability and toxicity. NPs cytotoxicity was investigated by cell viability, membrane integrity, mitochondrial membrane potential (MMP), reactive oxygen species (ROS) assays, and their genotoxicity by comet assay. Our results show that NPs surface p ...[more]