Ontology highlight
ABSTRACT:
SUBMITTER: Collart C
PROVIDER: S-EPMC3898016 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Collart Clara C Allen George E GE Bradshaw Charles R CR Smith James C JC Zegerman Philip P
Science (New York, N.Y.) 20130801 6148
The rapid, reductive early divisions of many metazoan embryos are followed by the midblastula transition (MBT), during which the cell cycle elongates and zygotic transcription begins. It has been proposed that the increasing nuclear to cytoplasmic (N/C) ratio is critical for controlling the events of the MBT. We show that four DNA replication factors--Cut5, RecQ4, Treslin, and Drf1--are limiting for replication initiation at increasing N/C ratios in vitro and in vivo in Xenopus laevis. The level ...[more]