Ontology highlight
ABSTRACT:
SUBMITTER: Rowe JB
PROVIDER: S-EPMC3898476 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Rowe J B JB Hughes L L Williams-Gray C H CH Bishop S S Fallon S S Barker R A RA Owen A M AM
Neurobiology of aging 20080827 6
We investigated whether the val(158)met functional polymorphism of catechol-o-methyltransferase influenced age-related changes in grey matter density and volume, both in healthy individuals (n=80, ages 18-79) and those with Parkinson's disease (n=50). Global grey matter volumes and voxelwise estimates of grey matter volume and density were determined from structural magnetic resonance images at 3T. Male and female ValVal homozygotes (low prefrontal cortical dopamine) had more grey matter in earl ...[more]