ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans.
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ABSTRACT:
SUBMITTER: Zamek-Gliszczynski MJ
PROVIDER: S-EPMC3898877 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans.
Zamek-Gliszczynski M J MJ Lee C A CA Poirier A A Bentz J J Chu X X Ellens H H Ishikawa T T Jamei M M Kalvass J C JC Nagar S S Pang K S KS Korzekwa K K Swaan P W PW Taub M E ME Zhao P P Galetin A A
Clinical pharmacology and therapeutics 20130225 1
This white paper provides a critical analysis of methods for estimating transporter kinetics and recommendations on proper parameter calculation in various experimental systems. Rational interpretation of transporter-knockout animal findings and application of static and dynamic physiologically based modeling approaches for prediction of human transporter-mediated pharmacokinetics and drug-drug interactions (DDIs) are presented. The objective is to provide appropriate guidance for the use of in ...[more]
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