Ontology highlight
ABSTRACT:
SUBMITTER: Nelson ER
PROVIDER: S-EPMC3899689 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Nelson Erik R ER Wardell Suzanne E SE Jasper Jeff S JS Park Sunghee S Suchindran Sunil S Howe Matthew K MK Carver Nicole J NJ Pillai Ruchita V RV Sullivan Patrick M PM Sondhi Varun V Umetani Michihisa M Geradts Joseph J McDonnell Donald P DP
Science (New York, N.Y.) 20131101 6162
Hypercholesterolemia is a risk factor for estrogen receptor (ER)-positive breast cancers and is associated with a decreased response of tumors to endocrine therapies. Here, we show that 27-hydroxycholesterol (27HC), a primary metabolite of cholesterol and an ER and liver X receptor (LXR) ligand, increases ER-dependent growth and LXR-dependent metastasis in mouse models of breast cancer. The effects of cholesterol on tumor pathology required its conversion to 27HC by the cytochrome P450 oxidase C ...[more]