Ontology highlight
ABSTRACT:
SUBMITTER: Avena P
PROVIDER: S-EPMC8946696 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Avena Paola P Casaburi Ivan I Zavaglia Lucia L Nocito Marta C MC La Padula Davide D Rago Vittoria V Dong Jing J Thomas Peter P Mineo Chieko C Sirianni Rosa R Shaul Philip W PW
Cancers 20220316 6
Cholesterol affects the proliferation of breast cancer (BC) and in particular of estrogen receptor-negative (ER-) BC. Cholesterol is converted to 27-hydroxycholesterol (27HC), which promotes the growth of ER+ BC. Potentially, 27HC can be involved in cholesterol-dependent ER- BC proliferation. Stable MDA-MB-231 silenced clones for CYP7B1 (27HC metabolizing enzyme) show an increased basal proliferation rate, which is not observed in the presence of lipoprotein-deprived serum. Furthermore, the trea ...[more]