Ontology highlight
ABSTRACT:
SUBMITTER: Hurley JM
PROVIDER: S-EPMC3900029 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Hurley Jennifer M JM Larrondo Luis F LF Loros Jennifer J JJ Dunlap Jay C JC
Molecular cell 20131205 6
Protein conformation dictates a great deal of protein function. A class of naturally unstructured proteins, termed intrinsically disordered proteins (IDPs), demonstrates that flexibility in structure can be as important mechanistically as rigid structure. At the core of the circadian transcription/translation feedback loop in Neurospora crassa is the protein FREQUENCY (FRQ), shown here shown to share many characteristics of IDPs. FRQ in turn binds to FREQUENCY-Interacting RNA Helicase (FRH), who ...[more]