Ontology highlight
ABSTRACT:
SUBMITTER: Wollenhaupt J
PROVIDER: S-EPMC5984983 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Wollenhaupt Jan J Henning Lisa M LM Sticht Jana J Becke Christian C Freund Christian C Santos Karine F KF Wahl Markus C MC
Biophysical journal 20180201 4
Precursor messenger RNA splicing is mediated by the spliceosome, a large and dynamic molecular machine composed of five small nuclear RNAs and numerous proteins. Many spliceosomal proteins are predicted to be intrinsically disordered or contain large disordered regions, but experimental validation of these predictions is scarce, and the precise functions of these proteins are often unclear. Here, we show via circular dichroism spectroscopy, dynamic light scattering, and NMR spectroscopy that the ...[more]