Ontology highlight
ABSTRACT:
SUBMITTER: Ma Z
PROVIDER: S-EPMC3900500 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Ma Zhen Z Koo Sangmo S Finnegan Micaela A MA Loskill Peter P Huebsch Nathaniel N Marks Natalie C NC Conklin Bruce R BR Grigoropoulos Costas P CP Healy Kevin E KE
Biomaterials 20131121 5
A human in vitro cardiac tissue model would be a significant advancement for understanding, studying, and developing new strategies for treating cardiac arrhythmias and related cardiovascular diseases. We developed an in vitro model of three-dimensional (3D) human cardiac tissue by populating synthetic filamentous matrices with cardiomyocytes derived from healthy wild-type volunteer (WT) and patient-specific long QT syndrome type 3 (LQT3) induced pluripotent stem cells (iPS-CMs) to mimic the con ...[more]