Ontology highlight
ABSTRACT:
SUBMITTER: Mosadegh B
PROVIDER: S-EPMC4107065 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Mosadegh Bobak B Dabiri Borna E BE Lockett Matthew R MR Derda Ratmir R Campbell Patrick P Parker Kevin Kit KK Whitesides George M GM
Advanced healthcare materials 20140212 7
In vitro models of ischemia have not historically recapitulated the cellular interactions and gradients of molecules that occur in a 3D tissue. This work demonstrates a paper-based 3D culture system that mimics some of the interactions that occur among populations of cells in the heart during ischemia. Multiple layers of paper containing cells, suspended in hydrogels, are stacked to form a layered 3D model of a tissue. Mass transport of oxygen and glucose into this 3D system can be modulated to ...[more]