Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Z
PROVIDER: S-EPMC5762557 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Cheng Zhi Z Sun Yu Y Niu Xiaoran X Shang Yingchun Y Ruan Jishou J Chen Ze Z Gao Shan S Zhang Tao T
Oncotarget 20171201 68
U1 small nuclear RNA (U1 snRNA), as one of the most abundant ncRNAs in human cells, plays an important role in splicing of pre-mRNAs. Compared to previous studies which have focused on the primary function of U1 snRNA and the neurodegenerative diseases caused by abnormalities of U1 snRNA, this study is to investigate how U1 snRNA over-expression affects the expression of mammal genes on a genome-wide scale. By comparing the gene expression profiles of U1 snRNA over-expressed cells with those of ...[more]