Structural basis for the divergent evolution of influenza B virus hemagglutinin.
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ABSTRACT:
SUBMITTER: Ni F
PROVIDER: S-EPMC3902124 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Structural basis for the divergent evolution of influenza B virus hemagglutinin.
Ni Fengyun F Kondrashkina Elena E Wang Qinghua Q
Virology 20130827 1-2
Influenza A and B viruses are responsible for the severe morbidity and mortality worldwide in annual influenza epidemics. Currently circulating influenza B virus belongs to the B/Victoria or B/Yamagata lineage that was diverged from each other about 30-40 years ago. However, a mechanistic understanding of their divergent evolution is still lacking. Here we report the crystal structures of influenza B/Yamanashi/166/1998 hemagglutinin (HA) belonging to B/Yamagata lineage and its complex with the a ...[more]
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