Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC2040455 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Wang Qinghua Q Tian Xia X Chen Xiaorui X Ma Jianpeng J
Proceedings of the National Academy of Sciences of the United States of America 20071017 43
Receptor-binding specificity of HA, the major surface glycoprotein of influenza virus, primarily determines the host ranges that the virus can infect. Influenza type B virus almost exclusively infects humans and contributes to the annual "flu" sickness. Here we report the structures of influenza B virus HA in complex with human and avian receptor analogs, respectively. These structures provide a structural basis for the different receptor-binding properties of influenza A and B virus HA molecule ...[more]