Ontology highlight
ABSTRACT:
SUBMITTER: Micozzi D
PROVIDER: S-EPMC3904506 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Micozzi Daniela D Carpi Francesco Martino FM Pucciarelli Stefania S Polzonetti Valeria V Polidori Paolo P Vilar Santiago S Williams Brian B Costanzi Stefano S Vincenzetti Silvia S
International journal of biological macromolecules 20131029
Human cytidine deaminase is an enzyme of the pyrimidine salvage pathways that metabolizes several cytosine nucleoside analogs used as prodrugs in chemotherapy. We carried out a characterization of the cytidine deaminase 79A>C and 208G>A Single Nucleotide Polymorphisms, in order to highlight their functional role and provide data that could help fine-tune the chemotherapic use of cytosine nucleosides in patients carrying the above mentioned SNPs. The 79A>C SNP results in a K27Q change in a protei ...[more]