Ontology highlight
ABSTRACT:
SUBMITTER: Garcia AR
PROVIDER: S-EPMC6534257 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Garcia Andreza R AR Oliveira Danielle M P DMP Claudia F Amaral Ana A Jesus Jéssica B JB Rennó Sodero Ana Carolina AC Souza Alessandra M T AMT Supuran Claudiu T CT Vermelho Alane B AB Rodrigues Igor A IA Pinheiro Anderson S AS
Journal of enzyme inhibition and medicinal chemistry 20191201 1
Inhibition of <i>Leishmania</i> arginase leads to a decrease in parasite growth and infectivity and thus represents an attractive therapeutic strategy. We evaluated the inhibitory potential of selected naturally occurring phenolic substances on <i>Leishmania infantum</i> arginase (ARGLi) and investigated their antileishmanial activity <i>in vivo</i>. ARGLi exhibited a <i>V</i><sub>max</sub> of 0.28 ± 0.016 mM/min and a <i>K</i><sub>m</sub> of 5.1 ± 1.1 mM for L-arginine. The phenylpropanoids ros ...[more]