Ontology highlight
ABSTRACT:
SUBMITTER: Andersson M
PROVIDER: S-EPMC3904665 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20131208 1
Heavy metals in cells are typically regulated by PIB-type ATPases. The first structure of the class, a Cu(+)-ATPase from Legionella pneumophila (LpCopA), outlined a copper transport pathway across the membrane, which was inferred to be occluded. Here we show by molecular dynamics simulations that extracellular water solvated the transmembrane (TM) domain, results indicative of a Cu(+)-release pathway. Furthermore, a new LpCopA crystal structure determined at 2.8-Å resolution, trapped in the prec ...[more]