Ontology highlight
ABSTRACT:
SUBMITTER: Tamminga C
PROVIDER: S-EPMC3906401 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Tamminga Cindy C Sedegah Martha M Maiolatesi Santina S Fedders Charlotte C Reyes Sharina S Reyes Anatalio A Vasquez Carlos C Alcorta Yolanda Y Chuang Ilin I Spring Michele M Kavanaugh Michael M Ganeshan Harini H Huang Jun J Belmonte Maria M Abot Esteban E Belmonte Arnel A Banania Joglenna J Farooq Fouzia F Murphy Jittawadee J Komisar Jack J Richie Nancy O NO Bennett Jason J Limbach Keith K Patterson Noelle B NB Bruder Joseph T JT Shi Meng M Miller Edward E Dutta Sheetij S Diggs Carter C Soisson Lorraine A LA Hollingdale Michael R MR Epstein Judith E JE Richie Thomas L TL
Human vaccines & immunotherapeutics 20130604 10
<h4>Background</h4>In a prior study, a DNA prime / adenovirus boost vaccine (DNA/Ad) expressing P. falciparum circumsporozoite protein (CSP) and apical membrane antigen-1 (AMA1) (NMRC-M3V-D/Ad-PfCA Vaccine) induced 27% protection against controlled human malaria infection (CHMI). To investigate the contribution of DNA priming, we tested the efficacy of adenovirus vaccine alone (NMRC-M3V-Ad-PfCA ) in a Phase 1 clinical trial.<h4>Methodology/principal findings</h4>The regimen was a single intramus ...[more]