Ontology highlight
ABSTRACT:
SUBMITTER: Chen YP
PROVIDER: S-EPMC3909564 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20131112 1
Employing a genetically modified yeast strain as a screening tool, 4-dimethylaminobenzoic acid (5) was isolated from the marine sediment-derived Streptomyces sp. CP27-53 as a weak yeast sirtuin (Sir2p) inhibitor. Using this compound as a scaffold, a series of disubstituted benzene derivatives were evaluated to elucidate the structure activity relationships for Sir2p inhibition. The results suggested that 4-alkyl or 4-alkylaminobenzoic acid is the key structure motif for Sir2p inhibitory activity ...[more]