Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC7801566 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents 20210112 2
Herein we report our investigation concerning the development of Human neutrophil elastase (hNE) inhibitors for the treatment of Acute Respiratory Distress Syndrome (ARDS). Various benzenesulfonic acid derived compounds were synthesized and evaluated as competitive inhibitors of hNE. Biological screening revealed that compound <b>4f</b> shows moderate inhibitory activity (IC<sub>50</sub> = 35.2 μM) against hNE. Compound <b>4f</b> was also superimposed onto the active center of hNE to understand ...[more]