Ontology highlight
ABSTRACT:
SUBMITTER: Yue X
PROVIDER: S-EPMC3909968 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Yue Xuan X Schwartz Jacob C JC Chu Yongjun Y Younger Scott T ST Gagnon Keith T KT Elbashir Sayda S Janowski Bethany A BA Corey David R DR
Nature chemical biology 20100627 8
Transcriptome studies reveal many noncoding transcripts overlapping 3' gene termini. The function of these transcripts is unknown. Here we have characterized transcription at the progesterone receptor (PR) locus and identified noncoding transcripts that overlap the 3' end of the gene. Small RNAs complementary to sequences beyond the 3' terminus of PR mRNA modulated expression of PR, recruited argonaute 2 to a 3' noncoding transcript, altered occupancy of RNA polymerase II, induced chromatin chan ...[more]