Ontology highlight
ABSTRACT:
SUBMITTER: Dowdy CR
PROVIDER: S-EPMC3909992 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Dowdy Christopher R CR Frederick Dana D Zaidi Sayyed K SK Colby Jennifer L JL Lian Jane B JB van Wijnen Andre J AJ Gerstein Rachel M RM Stein Janet L JL Stein Gary S GS
Experimental hematology 20130630 11
Definitive hematopoiesis requires the master hematopoietic transcription factor Runx1, which is a frequent target of leukemia-related chromosomal translocations. Several of the translocation-generated fusion proteins retain the DNA binding activity of Runx1, but lose subnuclear targeting and associated transactivation potential. Complete loss of these functions in vivo resembles Runx1 ablation, which causes embryonic lethality. We developed a knock-in mouse that expresses full-length Runx1 with ...[more]