Ontology highlight
ABSTRACT:
SUBMITTER: Ghanem LR
PROVIDER: S-EPMC6066754 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Ghanem Louis R LR Kromer Andrew A Silverman Ian M IM Ji Xinjun X Gazzara Matthew M Nguyen Nhu N Aguilar Gabrielle G Martinelli Massimo M Barash Yoseph Y Liebhaber Stephen A SA
Molecular and cellular biology 20180730 16
Formation of the mammalian hematopoietic system is under a complex set of developmental controls. Here, we report that mouse embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage. Compared to wild-type controls, transcript splicing analysis of the Pcbp2<sup>-/-</sup> embryonic liver reveals accentuated exclusion of an exon (exon 6) that encodes a highly conserved transcriptional control segment of the hematopoietic master regu ...[more]