Ontology highlight
ABSTRACT:
SUBMITTER: van Berkel SS
PROVIDER: S-EPMC3910272 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
van Berkel Sander S SS Brem Jürgen J Rydzik Anna M AM Salimraj Ramya R Cain Ricky R Verma Anil A Owens Raymond J RJ Fishwick Colin W G CW Spencer James J Schofield Christopher J CJ
Journal of medicinal chemistry 20130816 17
Metallo-β-lactamases (MBLs) are a growing threat to the use of almost all clinically used β-lactam antibiotics. The identification of broad-spectrum MBL inhibitors is hampered by the lack of a suitable screening platform, consisting of appropriate substrates and a set of clinically relevant MBLs. We report procedures for the preparation of a set of clinically relevant metallo-β-lactamases (i.e., NDM-1 (New Delhi MBL), IMP-1 (Imipenemase), SPM-1 (São Paulo MBL), and VIM-2 (Verona integron-encoded ...[more]