Ontology highlight
ABSTRACT:
SUBMITTER: Glickstein SB
PROVIDER: S-EPMC3396210 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Glickstein Sara B SB Moore Holly H Slowinska Bozena B Racchumi Joelle J Suh Minah M Chuhma Nao N Ross M Elizabeth ME
Development (Cambridge, England) 20071101 22
In contrast to cyclin D1 nulls (cD1-/-), mice without cyclin D2 (cD2-/-) lack cerebellar stellate interneurons; the reason for this is unknown. In the present study in cortex, we found a disproportionate loss of parvalbumin (PV) interneurons in cD2-/- mice. This selective reduction in PV subtypes was associated with reduced frequency of GABA-mediated inhibitory postsynaptic currents in pyramidal neurons, as measured by voltage-clamp recordings, and increased cortical sharp activity in the EEGs o ...[more]