Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC3910872 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Zhang Ying Y Jiang Xiaofei X Wang Yanyan Y Li Gang G Tian Yueru Y Liu Hong H Ai Fuqi F Ma Yiming Y Wang Bei B Ruan Feiyi F Rajakumar Kumar K
Antimicrobial agents and chemotherapy 20131125 2
Fifty-seven carbapenem-resistant Klebsiella pneumoniae isolates belonging to ST11 (50 isolates), ST423 (5 isolates), and two other sequence types were studied. All were positive for blaKPC-2, blaTEM-1, and blaCTX-M-14. SDS-PAGE analysis of six representative isolates demonstrated varied porin expression. Nevertheless, when blaKPC-2 was deleted, carbapenem resistance was markedly reduced. Additionally, SHV-12, DHA-1, and/or VIM-1 appeared to contribute to accessory carbapenemase activity. In cont ...[more]