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H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge.

ABSTRACT: The recent outbreak of H7N9 influenza virus infections in humans in China has raised concerns about the pandemic potential of this strain. Here, we test the efficacy of H3 stalk-based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge in the context of different administration routes as well as with a generic oil-in-water adjuvant similar to formulations licensed for use in humans.

SUBMITTER: Krammer F

PROVIDER: S-EPMC3911549 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge.

Krammer Florian F Margine Irina I Hai Rong R Flood Alexander A Hirsh Ariana A Tsvetnitsky Vadim V Chen Dexiang D Palese Peter P

Journal of virology 20131204 4

The recent outbreak of H7N9 influenza virus infections in humans in China has raised concerns about the pandemic potential of this strain. Here, we test the efficacy of H3 stalk-based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge in the context of different administration routes as well as with a generic oil-in-water adjuvant similar to formulations licensed for use i ...[more]

PMID: 24307585

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