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Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point.

ABSTRACT: Defining the characteristics of HIV-specific CD8(+) T cell responses that lead to viral control is crucial for vaccine development. We evaluated the differential impact of magnitude, polyfunctional capacity, and specificity of the CD8(+) response at approximately 6 months postinfection on the viral set point at 12 months in a cohort of HIV-infected individuals. High frequencies of Gag and Nef responses endowed with four functions were the best predictors of a low viral set point.

SUBMITTER: Riou C

PROVIDER: S-EPMC3911608 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Differential impact of magnitude, polyfunctional capacity, and specificity of HIV-specific CD8+ T cell responses on HIV set point.

Riou Catherine C Burgers Wendy A WA Mlisana Koleka K Koup Richard A RA Roederer Mario M Abdool Karim Salim S SS Williamson Carolyn C Gray Clive M CM

Journal of virology 20131113 3

Defining the characteristics of HIV-specific CD8(+) T cell responses that lead to viral control is crucial for vaccine development. We evaluated the differential impact of magnitude, polyfunctional capacity, and specificity of the CD8(+) response at approximately 6 months postinfection on the viral set point at 12 months in a cohort of HIV-infected individuals. High frequencies of Gag and Nef responses endowed with four functions were the best predictors of a low viral set point. ...[more]

PMID: 24227857

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