Ontology highlight
ABSTRACT:
SUBMITTER: Ndhlovu ZM
PROVIDER: S-EPMC4575777 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Ndhlovu Zaza M ZM Kamya Philomena P Mewalal Nikoshia N Kløverpris Henrik N HN Nkosi Thandeka T Pretorius Karyn K Laher Faatima F Ogunshola Funsho F Chopera Denis D Shekhar Karthik K Ghebremichael Musie M Ismail Nasreen N Moodley Amber A Malik Amna A Leslie Alasdair A Goulder Philip J R PJ Buus Søren S Chakraborty Arup A Dong Krista K Ndung'u Thumbi T Walker Bruce D BD
Immunity 20150908 3
CD8(+) T cells contribute to the control of HIV, but it is not clear whether initial immune responses modulate the viral set point. We screened high-risk uninfected women twice a week for plasma HIV RNA and identified 12 hyperacute infections. Onset of viremia elicited a massive HIV-specific CD8(+) T cell response, with limited bystander activation of non-HIV memory CD8(+) T cells. HIV-specific CD8(+) T cells secreted little interferon-γ, underwent rapid apoptosis, and failed to upregulate the i ...[more]