Ontology highlight
ABSTRACT:
SUBMITTER: Debattisti V
PROVIDER: S-EPMC3912536 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
The Journal of cell biology 20140127 3
Ablation of the mitochondrial fusion and endoplasmic reticulum (ER)-tethering protein Mfn2 causes ER stress, but whether this is just an epiphenomenon of mitochondrial dysfunction or a contributor to the phenotypes in mitofusin (Mfn)-depleted Drosophila melanogaster is unclear. In this paper, we show that reduction of ER dysfunction ameliorates the functional and developmental defects of flies lacking the single Mfn mitochondrial assembly regulatory factor (Marf). Ubiquitous or neuron- and muscl ...[more]