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Palladium-catalyzed ?-arylation of benzylic phosphine oxides.

ABSTRACT: A novel approach to prepare diarylmethyl phosphine oxides from benzyl phosphine oxides via deprotonative cross-coupling processes (DCCP) is reported. The optimization of the reaction was guided by High-Throughput Experimentation (HTE) techniques. The Pd(OAc)2/Xantphos-based catalyst enabled the reaction between benzyl diphenyl or dicyclohexyl phosphine oxide derivatives and aryl bromides in good to excellent yields (51-91%).

SUBMITTER: Montel S

PROVIDER: S-EPMC3913533 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Palladium-catalyzed α-arylation of benzylic phosphine oxides.

Montel Sonia S Jia Tiezheng T Walsh Patrick J PJ

Organic letters 20131202 1

A novel approach to prepare diarylmethyl phosphine oxides from benzyl phosphine oxides via deprotonative cross-coupling processes (DCCP) is reported. The optimization of the reaction was guided by High-Throughput Experimentation (HTE) techniques. The Pd(OAc)2/Xantphos-based catalyst enabled the reaction between benzyl diphenyl or dicyclohexyl phosphine oxide derivatives and aryl bromides in good to excellent yields (51-91%). ...[more]

PMID: 24295336

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