Unknown

Dataset Information

0

Palladium-catalyzed ?-arylation of benzylic phosphine oxides.

ABSTRACT: A novel approach to prepare diarylmethyl phosphine oxides from benzyl phosphine oxides via deprotonative cross-coupling processes (DCCP) is reported. The optimization of the reaction was guided by High-Throughput Experimentation (HTE) techniques. The Pd(OAc)2/Xantphos-based catalyst enabled the reaction between benzyl diphenyl or dicyclohexyl phosphine oxide derivatives and aryl bromides in good to excellent yields (51-91%).

SUBMITTER: Montel S 

PROVIDER: S-EPMC3913533 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Palladium-catalyzed α-arylation of benzylic phosphine oxides.

Montel Sonia S   Jia Tiezheng T   Walsh Patrick J PJ  

Organic letters 20131202 1

A novel approach to prepare diarylmethyl phosphine oxides from benzyl phosphine oxides via deprotonative cross-coupling processes (DCCP) is reported. The optimization of the reaction was guided by High-Throughput Experimentation (HTE) techniques. The Pd(OAc)2/Xantphos-based catalyst enabled the reaction between benzyl diphenyl or dicyclohexyl phosphine oxide derivatives and aryl bromides in good to excellent yields (51-91%). ...[more]

Similar Datasets

Unknown Palladium-catalyzed ?-arylation of benzylic phosphonates.
| S-EPMC3993846 | biostudies-other
Unknown Palladium-Catalyzed Benzylic C-H Arylation of Azaarylmethylamines.
| S-EPMC4880366 | biostudies-literature
Unknown Palladium-Catalyzed Benzylic Arylation of Pyridylmethyl Silyl Ethers: One-Pot Synthesis of Aryl(pyridyl)methanols.
| S-EPMC4887141 | biostudies-literature
Unknown Phosphine Oxides as Stabilizing Ligands for the Palladium-Catalyzed Cross-Coupling of Potassium Aryldimethylsilanolates.
| S-EPMC3498085 | biostudies-other
Unknown Phosphine-free palladium-catalyzed C-H bond arylation of free (N-H)-indoles and pyrroles.
| S-EPMC2971669 | biostudies-literature
Unknown Palladium-catalyzed arylation of cyanamides.
| S-EPMC4113087 | biostudies-literature
Unknown Palladium-Catalyzed Arylation of Fluoroalkylamines.
| S-EPMC4699424 | biostudies-literature
Unknown Palladium-catalyzed benzylic C(sp<sup>3</sup>)-H carbonylative arylation of azaarylmethyl amines with aryl bromides.
| S-EPMC8372623 | biostudies-literature
Unknown Enantioselective Cu-Catalyzed Arylation of Secondary Phosphine Oxides with Diaryliodonium Salts toward the Synthesis of P-Chiral Phosphines.
| S-EPMC5065240 | biostudies-literature
Unknown Palladium-Catalyzed ?-Arylation of ?-Keto Esters.
| S-EPMC5598777 | biostudies-literature