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Palladium-catalyzed ?-arylation of 2-chloroacetates and 2-chloroacetamides.

ABSTRACT: A method has been developed for the Pd-catalyzed synthesis of ?-(hetero)aryl esters and amides through a Suzuki-Miyaura cross-coupling reaction. This method avoids the use of strong base, does not necessitate inert or low temperature formation of reagents, and does not require the use of a large excess of organometallic reagent. Utilization of organotrifluoroborate salts as nucleophilic partners allows a variety of functional groups and heterocyclic compounds to be tolerated.

SUBMITTER: Molander GA

PROVIDER: S-EPMC3668638 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Palladium-catalyzed α-arylation of 2-chloroacetates and 2-chloroacetamides.

Molander Gary A GA Traister Kaitlin M KM Barcellos Thiago T

The Journal of organic chemistry 20130409 8

A method has been developed for the Pd-catalyzed synthesis of α-(hetero)aryl esters and amides through a Suzuki-Miyaura cross-coupling reaction. This method avoids the use of strong base, does not necessitate inert or low temperature formation of reagents, and does not require the use of a large excess of organometallic reagent. Utilization of organotrifluoroborate salts as nucleophilic partners allows a variety of functional groups and heterocyclic compounds to be tolerated. ...[more]

PMID: 23570264

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