Ontology highlight
ABSTRACT:
SUBMITTER: Brosens JJ
PROVIDER: S-EPMC3915549 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Scientific reports 20140206
Human embryos frequently harbor large-scale complex chromosomal errors that impede normal development. Affected embryos may fail to implant although many first breach the endometrial epithelium and embed in the decidualizing stroma before being rejected via mechanisms that are poorly understood. Here we show that developmentally impaired human embryos elicit an endoplasmic stress response in human decidual cells. A stress response was also evident upon in vivo exposure of mouse uteri to culture ...[more]