Ontology highlight
ABSTRACT:
SUBMITTER: Huang K
PROVIDER: S-EPMC3916755 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Huang Kevin K Shen Yin Y Xue Zhigang Z Bibikova Marina M April Craig C Liu Zhenshan Z Cheng Linzhao L Nagy Andras A Pellegrini Matteo M Fan Jian-Bing JB Fan Guoping G
Stem cell reports 20131226 1
Whether human induced pluripotent stem cells (hiPSCs) are epigenetically identical to human embryonic stem cells (hESCs) has been debated in the stem cell field. In this study, we analyzed DNA methylation patterns in a large number of hiPSCs (n = 114) and hESCs (n = 155), and identified a panel of 82 CpG methylation sites that can distinguish hiPSCs from hESCs with high accuracy. We show that 12 out of the 82 CpG sites were subject to hypermethylation in part by DNMT3B. Notably, DNMT3B contribut ...[more]