Ontology highlight
ABSTRACT:
SUBMITTER: Horii T
PROVIDER: S-EPMC5004787 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
The Journal of reproduction and development 20160505 4
Vertebrate genomes are highly methylated at cytosine residues in CpG sequences. CpG methylation plays an important role in epigenetic gene silencing and genome stability. Compared with other epigenetic modifications, CpG methylation is thought to be relatively stable; however, it is sometimes affected by environmental changes, leading to epigenetic instability and disease. CpG methylation is reversible and regulated by DNA methyltransferases and demethylases including ten-eleven translocation. H ...[more]