Ontology highlight
ABSTRACT:
SUBMITTER: Perets R
PROVIDER: S-EPMC3917315 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Perets Ruth R Wyant Gregory A GA Muto Katherine W KW Bijron Jonathan G JG Poole Barish B BB Chin Kenneth T KT Chen Jin Yun H JY Ohman Anders W AW Stepule Corey D CD Kwak Soongu S Karst Alison M AM Hirsch Michelle S MS Setlur Sunita R SR Crum Christopher P CP Dinulescu Daniela M DM Drapkin Ronny R
Cancer cell 20131201 6
High-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges. Although the traditional model of carcinogenesis has focused on the ovary as a tumor initiation site, recent studies suggest that there may be additional sites of origin outside the ovary, namely the secretory cells of the fallopian tube. Our study demonstrates that high-grade serous tumors can originate in fallopian tubal secretory epithelial cells and also establishes serous tubal intraepithelial carc ...[more]