Ontology highlight
ABSTRACT:
SUBMITTER: Hua G
PROVIDER: S-EPMC4791205 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Hua G G Lv X X He C C Remmenga S W SW Rodabough K J KJ Dong J J Yang L L Lele S M SM Yang P P Zhou J J Karst A A Drapkin R I RI Davis J S JS Wang C C
Oncogene 20150914 17
Accumulating evidence indicates that ovarian high-grade serous carcinoma (HGSC) originates from fallopian tube secretory epithelial cells (FTSECs). However, the molecular mechanisms underlying the initiation and progression of HGSC derived from FTSECs remains unclear. In this study, we found that the Hippo/Yes-associated protein (YAP) signaling pathway has a critical role in the initiation and progression of fallopian tube and ovarian HGSC. Importantly, YAP was overexpressed in inflammatory and ...[more]