Ontology highlight
ABSTRACT:
SUBMITTER: Christiansen AE
PROVIDER: S-EPMC3917606 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Christiansen Audrey E AE Ding Tian T Bergmann Andreas A
Mechanisms of development 20120605 5-8
Deregulation of the Hedgehog (Hh) signaling pathway is associated with the development of human cancer including medullobastoma and basal cell carcinoma. Loss of Patched or activation of Smoothened in mouse models increases the occurrence of tumors. Likewise, in a Drosophila eye model, deregulated Hedgehog signaling causes overgrowth of eye and head tissues. Surprisingly, we show that cells with deregulated Hh signaling do not or only little contribute to the tissue overgrowth. Instead, they bec ...[more]