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Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development.

ABSTRACT: Although recent studies have shown that brown adipose tissue (BAT) arises from progenitor cells that also give rise to skeletal muscle, the developmental signals that control the formation of BAT remain largely unknown. Here, we show that brown preadipocytes possess primary cilia and can respond to Hedgehog (Hh) signaling. Furthermore, cell-autonomous activation of Hh signaling blocks early brown-preadipocyte differentiation, inhibits BAT formation in vivo, and results in replacement of neck BAT with poorly differentiated skeletal muscle. Finally, we show that Hh signaling inhibits BAT formation partially through up-regulation of chicken ovalbumin upstream promoter transcription factor II (COUP-TFII). Taken together, our studies uncover a previously unidentified role for Hh as an inhibitor of BAT development.

SUBMITTER: Nosavanh L

PROVIDER: S-EPMC4413261 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development.

Nosavanh LaGina L Yu Da-Hai DH Jaehnig Eric J EJ Tong Qiang Q Shen Lanlan L Chen Miao-Hsueh MH

Proceedings of the National Academy of Sciences of the United States of America 20150406 16

Although recent studies have shown that brown adipose tissue (BAT) arises from progenitor cells that also give rise to skeletal muscle, the developmental signals that control the formation of BAT remain largely unknown. Here, we show that brown preadipocytes possess primary cilia and can respond to Hedgehog (Hh) signaling. Furthermore, cell-autonomous activation of Hh signaling blocks early brown-preadipocyte differentiation, inhibits BAT formation in vivo, and results in replacement of neck BAT ...[more]

PMID: 25848030

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