Ontology highlight
ABSTRACT:
SUBMITTER: Gao C
PROVIDER: S-EPMC3917779 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Gao Chan C Kozlowska Anna A Nechaev Sergey S Li Haiqing H Zhang Qifang Q Hossain Dewan M S DM Kowolik Claudia M CM Chu Peiguo P Swiderski Piotr P Diamond Don J DJ Pal Sumanta K SK Raubitschek Andrew A Kortylewski Marcin M
Cancer research 20131023 24
Cancer radiotherapy may be immunogenic, but it is unclear why its immunogenic effects are rarely sufficient to prevent tumor recurrence. Here, we report a novel Toll-like receptor 9 (TLR9)-dependent mechanism that initiates tumor regrowth after local radiotherapy. Systemic inhibition of TLR9, but not TLR4, delayed tumor recurrence in mouse models of B16 melanoma, MB49 bladder cancer, and CT26 colon cancer after localized high-dose tumor irradiation. Soluble factors in the microenvironment of reg ...[more]