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Using the PfEMP1 head structure binding motif to deal a blow at severe malaria.

ABSTRACT: Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to ?1 million deaths and ?100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this ?300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria.

SUBMITTER: Patarroyo ME 

PROVIDER: S-EPMC3917906 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Using the PfEMP1 head structure binding motif to deal a blow at severe malaria.

Patarroyo Manuel E ME   Alba Martha Patricia MP   Curtidor Hernando H   Vanegas Magnolia M   Almonacid Hannia H   Patarroyo Manuel A MA  

PloS one 20140207 2

Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to ∼1 million deaths and ∼100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An  ...[more]

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