Ontology highlight
ABSTRACT:
SUBMITTER: Lennartz F
PROVIDER: S-EPMC5374107 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lennartz Frank F Adams Yvonne Y Bengtsson Anja A Olsen Rebecca W RW Turner Louise L Ndam Nicaise T NT Ecklu-Mensah Gertrude G Moussiliou Azizath A Ofori Michael F MF Gamain Benoit B Lusingu John P JP Petersen Jens E V JE Wang Christian W CW Nunes-Silva Sofia S Jespersen Jakob S JS Lau Clinton K Y CK Theander Thor G TG Lavstsen Thomas T Hviid Lars L Higgins Matthew K MK Jensen Anja T R AT
Cell host & microbe 20170301 3
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display parasite proteins of the PfEMP1 family that bind various endothelial receptors. Despite the importance of cerebral malaria, a binding phenotype linked to its symptoms has not been identified. Here, we used structural biology to determine how a group of PfEMP1 proteins interacts with intercellular adhesion molecule 1 (ICAM-1) ...[more]