Caspases as therapeutic targets.
Ontology highlight
ABSTRACT:
SUBMITTER: Howley B
PROVIDER: S-EPMC3918066 | biostudies-literature | 2008 Sep-Oct
REPOSITORIES: biostudies-literature
Publications
Caspases as therapeutic targets.
Journal of cellular and molecular medicine 20080224 5A
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; deregulation of their activation or expression can lead to the development of conditions such as neurodegenerative and autoinflammatory disorders. This review details the different caspase-associated disorders while focusing on caspase-1 inhibition as a potential therapeutic s ...[more]
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