Ontology highlight
ABSTRACT:
SUBMITTER: Troy CM
PROVIDER: S-EPMC4322071 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Troy Carol M CM Jean Ying Y YY
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20150101 1
Specific therapies for neurologic diseases such as Alzheimer's disease provide the potential for better clinical outcomes. Expression of caspases in the brain is developmentally regulated, and dysregulated in neurologic disease, supporting that caspases may be therapeutic targets. The activity of caspases is carefully regulated via binding partners, cleavage, or endogenous inhibitors to prevent spontaneous activation, which could lead to aberrant cell death. This review serves as a brief examina ...[more]