Ontology highlight
ABSTRACT:
SUBMITTER: Smith C
PROVIDER: S-EPMC3918921 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Smith Corey C Gras Stephanie S Brennan Rebekah M RM Bird Nicola L NL Valkenburg Sophie A SA Twist Kelly-Anne KA Burrows Jacqueline M JM Miles John J JJ Chambers Daniel D Bell Scott S Campbell Scott S Kedzierska Katherine K Burrows Scott R SR Rossjohn Jamie J Khanna Rajiv R
Scientific reports 20140210
Exposure to naturally occurring variants of herpesviruses in clinical settings can have a dramatic impact on anti-viral immunity. Here we have evaluated the molecular imprint of variant peptide-MHC complexes on the T-cell repertoire during human cytomegalovirus (CMV) infection and demonstrate that primary co-infection with genetic variants of CMV was coincident with development of strain-specific T-cell immunity followed by emergence of cross-reactive virus-specific T-cells. Cross-reactive CMV-s ...[more]