Ontology highlight
ABSTRACT:
SUBMITTER: Genc O
PROVIDER: S-EPMC3919271 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Genc Ozgür O Kochubey Olexiy O Toonen Ruud F RF Verhage Matthijs M Schneggenburger Ralf R
eLife 20140211
Transmitter release at synapses is regulated by preceding neuronal activity, which can give rise to short-term enhancement of release like post-tetanic potentiation (PTP). Diacylglycerol (DAG) and Protein-kinase C (PKC) signaling in the nerve terminal have been widely implicated in the short-term modulation of transmitter release, but the target protein of PKC phosphorylation during short-term enhancement has remained unknown. Here, we use a gene-replacement strategy at the calyx of Held, a larg ...[more]