Ontology highlight
ABSTRACT:
SUBMITTER: Chang HW
PROVIDER: S-EPMC3919589 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Chang Han-Wen HW Kulaeva Olga I OI Shaytan Alexey K AK Kibanov Mikhail M Kuznedelov Konstantin K Severinov Konstantin V KV Kirpichnikov Mikhail P MP Clark David J DJ Studitsky Vasily M VM
Nucleic acids research 20131113 3
Maintenance of nucleosomal structure in the cell nuclei is essential for cell viability, regulation of gene expression and normal aging. Our previous data identified a key intermediate (a small intranucleosomal DNA loop, Ø-loop) that is likely required for nucleosome survival during transcription by RNA polymerase II (Pol II) through chromatin, and suggested that strong nucleosomal pausing guarantees efficient nucleosome survival. To evaluate these predictions, we analysed transcription through ...[more]