Ontology highlight
ABSTRACT:
SUBMITTER: Erkina TY
PROVIDER: S-EPMC5029090 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Erkina Tamara Y TY Erkine Alexandre M AM
Epigenetics & chromatin 20160920
After more than three decades since the discovery of transcription activation domains (ADs) in gene-specific activators, the mechanism of their function remains enigmatic. The widely accepted model of direct recruitment by ADs of co-activators and basal transcriptional machinery components, however, is not always compatible with the short size yet very high degree of sequence randomness and intrinsic structural disorder of natural and synthetic ADs. In this review, we formulate the basis for an ...[more]