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ABSTRACT:
SUBMITTER: Burkovics P
PROVIDER: S-EPMC3919600 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Burkovics Peter P Sebesta Marek M Balogh David D Haracska Lajos L Krejci Lumir L
Nucleic acids research 20131105 3
Stalling of replication forks at unrepaired DNA lesions can result in discontinuities opposite the damage in the newly synthesized DNA strand. Translesion synthesis or facilitating the copy from the newly synthesized strand of the sister duplex by template switching can overcome such discontinuities. During template switch, a new primer-template junction has to be formed and two mechanisms, including replication fork reversal and D-loop formation have been suggested. Genetic evidence indicates a ...[more]